[HTML][HTML] Mitochondrial outer membrane permeability change and hypersensitivity to digitonin early in staurosporine-induced apoptosis
S Duan, P Hájek, C Lin, SK Shin, G Attardi… - Journal of Biological …, 2003 - ASBMB
We have shown here that the apoptosis inducer staurosporine causes an early decrease in
the endogenous respiration rate in intact 143B. TK− cells. On the other hand, the activity of
cytochrome c oxidase is unchanged for the first 8 h after staurosporine treatment, as
determined by oxygen consumption measurements in intact cells. The decrease in the
endogenous respiration rate precedes the release of cytochromec from mitochondria.
Moreover, we have ruled out caspases, permeability transition, and protein kinase C …
the endogenous respiration rate in intact 143B. TK− cells. On the other hand, the activity of
cytochrome c oxidase is unchanged for the first 8 h after staurosporine treatment, as
determined by oxygen consumption measurements in intact cells. The decrease in the
endogenous respiration rate precedes the release of cytochromec from mitochondria.
Moreover, we have ruled out caspases, permeability transition, and protein kinase C …