Mesenchymal stem cells are renotropic, helping to repair the kidney and improve function in acute renal failure

M Morigi, B Imberti, C Zoja, D Corna… - Journal of the …, 2004 - journals.lww.com
Injury to a target organ can be sensed by bone marrow stem cells that migrate to the site of
damage, undergo differentiation, and promote structural and functional repair. This
remarkable stem cell capacity prompted an investigation of the potential of mesenchymal
and hematopoietic stem cells to cure acute renal failure. The model of renal injury induced in
mice by the anticancer agent cisplatin was chosen. Injection of mesenchymal stem cells of
male bone marrow origin remarkably protected cisplatin-treated syngeneic female mice from …