Zanamivir in the prevention of influenza among healthy adults: a randomized controlled trial
AS Monto, DP Robinson, ML Herlocher, JM Hinson Jr… - Jama, 1999 - jamanetwork.com
ContextThe neuraminidase inhibitor zanamivir, a sialic acid analog administered directly to
the respiratory tract, has been demonstrated in clinical studies to be effective in treatment of
type A and B influenza. It has also been shown to prevent influenza infection and disease in
an experimental model. ObjectiveTo examine the efficacy of zanamivir, administered once
daily, in the prevention of influenza infection and disease. DesignDouble-blind, randomized,
placebo-controlled trial. SettingTwo midwestern university communities. ParticipantsA total …
the respiratory tract, has been demonstrated in clinical studies to be effective in treatment of
type A and B influenza. It has also been shown to prevent influenza infection and disease in
an experimental model. ObjectiveTo examine the efficacy of zanamivir, administered once
daily, in the prevention of influenza infection and disease. DesignDouble-blind, randomized,
placebo-controlled trial. SettingTwo midwestern university communities. ParticipantsA total …