Rational design of potent sialidase-based inhibitors of influenza virus replication
M Von Itzstein, WY Wu, GB Kok, MS Pegg, JC Dyason… - Nature, 1993 - nature.com
M Von Itzstein, WY Wu, GB Kok, MS Pegg, JC Dyason, B Jin, T Van Phan, ML Smythe…
Nature, 1993•nature.comTwo potent inhibitors based on the crystal structure of influenza virus sialidase have been
designed. These compounds are effective inhibitors not only of the enzyme, but also of the
virus in cell culture and in animal models. The results provide an example of the power of
rational, computer-assisted drug design, as well as indicating significant progress in the
development of a new therapeutic or prophylactic treatment for influenza infection.
designed. These compounds are effective inhibitors not only of the enzyme, but also of the
virus in cell culture and in animal models. The results provide an example of the power of
rational, computer-assisted drug design, as well as indicating significant progress in the
development of a new therapeutic or prophylactic treatment for influenza infection.
Abstract
Two potent inhibitors based on the crystal structure of influenza virus sialidase have been designed. These compounds are effective inhibitors not only of the enzyme, but also of the virus in cell culture and in animal models. The results provide an example of the power of rational, computer-assisted drug design, as well as indicating significant progress in the development of a new therapeutic or prophylactic treatment for influenza infection.
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