Inappropriate elevation of serum leptin levels in children with chronic renal failure. European Study Group for Nutritional Treatment of Chronic Renal Failure in …

M Daschner, B Tönshoff, WF Blum… - Journal of the …, 1998 - journals.lww.com
Decreased spontaneous nutrient intake is a frequent clinical problem in patients with chronic
renal failure (CRF). Leptin, the recently characterized gene product of the obese gene, is
produced by adipocytes and is thought to act as an afferent satiety signal on the appetite
and satiety centers of the brain. Serum leptin levels were investigated in 134 pediatric
patients in different stages of CRF to evaluate a possible relationship between leptin, GFR,
and spontaneous energy intake. Serum leptin levels, measured by a specific RIA, were …