[HTML][HTML] Regulation of amyloid protein precursor (APP) binding to Collagen and mapping of the binding sites on APP and collagen type I (∗)
D Beher, L Hesse, CL Masters, G Multhaup - Journal of biological chemistry, 1996 - ASBMB
The specific binding of the amyloid precursor protein (APP) to extracellular matrix molecules
suggests that APP regulates cell interactions and has a function as a cell adhesion molecule
and/or substrate adhesion molecule. On the molecular level APP has binding sites for
collagen, laminin, and glycosaminoglycans which is a characteristic feature of cell adhesion
molecules. We have examined the interactions between the APP and collagen types I and IV
and identified the corresponding binding sites on APP and collagen type I. We show that …
suggests that APP regulates cell interactions and has a function as a cell adhesion molecule
and/or substrate adhesion molecule. On the molecular level APP has binding sites for
collagen, laminin, and glycosaminoglycans which is a characteristic feature of cell adhesion
molecules. We have examined the interactions between the APP and collagen types I and IV
and identified the corresponding binding sites on APP and collagen type I. We show that …