Considerable progress has been made in many aspects of osteogenesis imperfecta. The
international Sillence classification of osteogenesis imperfecta is being expanded to include
a greater range of subgroups of patients. Attempts are being made to identify the genes
causing forms of osteogenesis imperfecta and related syndromes that are not caused by
mutations of the Type I collagen genes. In medium-term studies, bisphosphonate treatment
has been shown to be the first method of treatment to improve the clinical course of the …