Possible association of infertility with sperm-specific abnormality of CD46
M Kitamura, K Matsumiya, M Yamanaka… - Journal of reproductive …, 1997 - Elsevier
Three infertile patients fulfilling normal or subnormal criteria on routine semen analysis
showed abnormal sperm CD46 (membrane cofactor protein of complement) by SDS-
PAGE/immunoblotting analysis using a panel of monoclonal antibodies. The sperm CD46
isoform has been reported to be associated with sperm-egg interaction. These three patients
expressed normal CD46 isoforms on their lymphocytes and granulocytes. Sperm-specific
abnormalities in these proteins thus parallel male infertility, suggesting a new category of …
showed abnormal sperm CD46 (membrane cofactor protein of complement) by SDS-
PAGE/immunoblotting analysis using a panel of monoclonal antibodies. The sperm CD46
isoform has been reported to be associated with sperm-egg interaction. These three patients
expressed normal CD46 isoforms on their lymphocytes and granulocytes. Sperm-specific
abnormalities in these proteins thus parallel male infertility, suggesting a new category of …