[HTML][HTML] Activation-independent parathyroid hormone receptor internalization is regulated by NHERF1 (EBP50)
WB Sneddon, CA Syme, A Bisello, CE Magyar… - Journal of Biological …, 2003 - ASBMB
Parathyroid hormone (PTH) regulates extracellular calcium homeostasis through the type 1
PTH receptor (PTH1R) expressed in kidney and bone. The PTH1R undergoes β-
arrestin/dynamin-mediated endocytosis in response to the biologically active forms of PTH,
PTH-(1–34), and PTH-(1–84). We now show that amino-truncated forms of PTH that do not
activate the PTH1R nonetheless induce PTH1R internalization in a cell-specific pattern.
Activation-independent PTH1R endocytosis proceeds through a distinct arrestin …
PTH receptor (PTH1R) expressed in kidney and bone. The PTH1R undergoes β-
arrestin/dynamin-mediated endocytosis in response to the biologically active forms of PTH,
PTH-(1–34), and PTH-(1–84). We now show that amino-truncated forms of PTH that do not
activate the PTH1R nonetheless induce PTH1R internalization in a cell-specific pattern.
Activation-independent PTH1R endocytosis proceeds through a distinct arrestin …