[HTML][HTML] Smad4 and β-catenin co-activators functionally interact with lymphoid-enhancing factor to regulate graded expression of Msx2
SM Hussein, EK Duff, C Sirard - Journal of Biological Chemistry, 2003 - ASBMB
Recent in vivo evidence suggests that Wnt signaling plays a central role in determining the
fate of stem cells in the ectoderm and in the neural crest by modulating bone morphogenetic
protein (BMP) levels, which, in turn, influence Msx gene expression. However, the molecular
mechanism regulating the expression of the Msx genes as key regulators of cell fate has not
been elucidated. Here we show in murine embryonic stem cells that BMP-dependent
activation of Msx2 is mediated via the cooperative binding of Smad4 at two Smad binding …
fate of stem cells in the ectoderm and in the neural crest by modulating bone morphogenetic
protein (BMP) levels, which, in turn, influence Msx gene expression. However, the molecular
mechanism regulating the expression of the Msx genes as key regulators of cell fate has not
been elucidated. Here we show in murine embryonic stem cells that BMP-dependent
activation of Msx2 is mediated via the cooperative binding of Smad4 at two Smad binding …