[HTML][HTML] Specific inhibitors of p38 mitogen-activated protein kinase block 3T3-L1 adipogenesis
JA Engelman, MP Lisanti, PE Scherer - Journal of Biological Chemistry, 1998 - ASBMB
SB203580 and SB202190, pyridinyl imidazoles that selectively inhibit p38 mitogen-activated
protein (MAP) kinase, are widely utilized to assess the physiological roles of p38. Here, we
demonstrate that treatment of 3T3-L1 fibroblasts with these p38 MAP kinase inhibitors
prevents their differentiation into adipocytes as judged by an absence of lipid accumulation,
a lack of expression of adipocyte-specific genes, and a fibroblastic morphological
appearance. In 3T3-L1 fibroblasts and developing adipocytes, p38 is active. p38 activity …
protein (MAP) kinase, are widely utilized to assess the physiological roles of p38. Here, we
demonstrate that treatment of 3T3-L1 fibroblasts with these p38 MAP kinase inhibitors
prevents their differentiation into adipocytes as judged by an absence of lipid accumulation,
a lack of expression of adipocyte-specific genes, and a fibroblastic morphological
appearance. In 3T3-L1 fibroblasts and developing adipocytes, p38 is active. p38 activity …