Functional effect of the R110Q IL13 genetic variant alone and in combination with IL4RA genetic variants
W Chen, MB Ericksen, LS Levin… - Journal of Allergy and …, 2004 - Elsevier
BACKGROUND: IL-13 is a key mediator of allergic asthma. IL-13 mediates its effects via its
receptor, a heterodimer composed of IL-4Rα and IL-13Rα1. Polymorphic variants of both IL-
13 and IL-4Rα have been shown to be associated with atopy. OBJECTIVE: We examined
the functional consequences of the Q110 IL-13 variant in vitro and in vivo to determine
whether it displays enhanced functional activity compared with R110 IL-13, both in the
context of I50Q551 IL-4Rα and of the atopy-associated variant V50R551 IL-4Rα. METHODS …
receptor, a heterodimer composed of IL-4Rα and IL-13Rα1. Polymorphic variants of both IL-
13 and IL-4Rα have been shown to be associated with atopy. OBJECTIVE: We examined
the functional consequences of the Q110 IL-13 variant in vitro and in vivo to determine
whether it displays enhanced functional activity compared with R110 IL-13, both in the
context of I50Q551 IL-4Rα and of the atopy-associated variant V50R551 IL-4Rα. METHODS …