Associations between total serum IgE levels and the 6 potentially functional variants within the genes IL4, IL13, and IL4RA in German children: the German Multicenter …
X Liu, TH Beaty, P Deindl, SK Huang, S Lau… - Journal of allergy and …, 2003 - Elsevier
Background: Increased total serum IgE levels are a common characteristic of atopic
disorders. Six potentially functional variants, including C-590T in the IL4 gene, C-1055T and
Arg130Gln in the IL13 gene, and Ile50Val, Ser478Pro, and Gln551Arg in the IL4RA gene,
have been evaluated for their involvement in the control of total serum IgE levels and related
atopic disorders, but the results of these studies have been inconsistent. Objective: We
examined whether these 6 variants had genotypic effects on total serum IgE levels in 823 …
disorders. Six potentially functional variants, including C-590T in the IL4 gene, C-1055T and
Arg130Gln in the IL13 gene, and Ile50Val, Ser478Pro, and Gln551Arg in the IL4RA gene,
have been evaluated for their involvement in the control of total serum IgE levels and related
atopic disorders, but the results of these studies have been inconsistent. Objective: We
examined whether these 6 variants had genotypic effects on total serum IgE levels in 823 …