Role of cytokines in the pathogenesis of inflammatory bowel disease
KA Papadakis, SR Targan - Annual review of medicine, 2000 - annualreviews.org
Recent advances in the drug treatment of inflammatory bowel disease (IBD) have paralleled
our understanding of the pathophysiology of ulcerative colitis and Crohn's disease. Several
proinflammatory and immune-regulatory cytokines are upregulated in the mucosa of patients
with IBD, and differences and similarities in the cytokine profiles of ulcerative colitis and
Crohn's disease have been elucidated. Several clinical trials involving a chimeric anti-TNF-α
(tumor necrosis factor-α) antibody have shown marked clinical benefit in the majority of …
our understanding of the pathophysiology of ulcerative colitis and Crohn's disease. Several
proinflammatory and immune-regulatory cytokines are upregulated in the mucosa of patients
with IBD, and differences and similarities in the cytokine profiles of ulcerative colitis and
Crohn's disease have been elucidated. Several clinical trials involving a chimeric anti-TNF-α
(tumor necrosis factor-α) antibody have shown marked clinical benefit in the majority of …