The Drosophila roughened mutation: activation of a rap homolog disrupts eye development and interferes with cell determination
IK Hariharan, RW Carthew, GM Rubin - Cell, 1991 - cell.com
IK Hariharan, RW Carthew, GM Rubin
Cell, 1991•cell.comRoughened Is a dominant mutation of D. melanogaster that disrupts eye development. The
majority of the ommatidia in the adult eye lack a single photoreceptor cell, which is most
commonly the R7 cell. The Roughened mutation disrupts the early stages of photorecep tor
cell determination. Roughened Is a dominant gainof-function mutation that results from a
single amino acid change (PhelS7 to Leu) in the Drosophila Rap7 protein. Loss of function
Rap1 mutations are lethal. Drosophila Rap1 protein Is 88% Identical to human rapIA/K-rev7 …
majority of the ommatidia in the adult eye lack a single photoreceptor cell, which is most
commonly the R7 cell. The Roughened mutation disrupts the early stages of photorecep tor
cell determination. Roughened Is a dominant gainof-function mutation that results from a
single amino acid change (PhelS7 to Leu) in the Drosophila Rap7 protein. Loss of function
Rap1 mutations are lethal. Drosophila Rap1 protein Is 88% Identical to human rapIA/K-rev7 …
Summary
Roughened Is a dominant mutation of D. melanogaster that disrupts eye development. The majority of the ommatidia in the adult eye lack a single photoreceptor cell, which is most commonly the R7 cell. The Roughened mutation disrupts the early stages of photorecep tor cell determination. Roughened Is a dominant gainof-function mutation that results from a single amino acid change (PhelS7 to Leu) in the Drosophila Rap7 protein. Loss of function Rap1 mutations are lethal. Drosophila Rap1 protein Is 88% Identical to human rapIA/K-rev7 protein, a putative antagonist of ras action.
cell.com