Ferric ion sequestering agents. 2. Kinetics and mechanism of iron removal from transferrin by enterobactin and synthetic tricatechols
CJ Carrano, KN Raymond - Journal of the American Chemical …, 1979 - ACS Publications
CJ Carrano, KN Raymond
Journal of the American Chemical Society, 1979•ACS PublicationsThe apparent first-order rate constants for iron removal from transferrin by the synthetic
sequestering agents 1, 5, 10-./V, yV',/V"-tris (5-sulfo-2, 3-dihydroxybenzoyl) triazadecane (3,
4-LiCAMS), 1, 3, 5-M/V', A,"-tris (2, 3-dihydroxybenzoyl) aminomethylbenzene (MECAM),
and the natural siderophore enterobactin (ent) have been determined at 25 C. One of these
compounds, 3, 4-LICAMS, was examined in detail, and the mechanism of its removal of iron
from transferrin elucidated. The 3, 4-LICAMS ligand is observed to form a complex with …
sequestering agents 1, 5, 10-./V, yV',/V"-tris (5-sulfo-2, 3-dihydroxybenzoyl) triazadecane (3,
4-LiCAMS), 1, 3, 5-M/V', A,"-tris (2, 3-dihydroxybenzoyl) aminomethylbenzene (MECAM),
and the natural siderophore enterobactin (ent) have been determined at 25 C. One of these
compounds, 3, 4-LICAMS, was examined in detail, and the mechanism of its removal of iron
from transferrin elucidated. The 3, 4-LICAMS ligand is observed to form a complex with …
Abstract
The apparent first-order rate constants for iron removal from transferrin by the synthetic sequestering agents
1, 5, 10-./V, yV',/V"-tris (5-sulfo-2, 3-dihydroxybenzoyl) triazadecane (3, 4-LiCAMS), 1, 3, 5-M/V', A,"-tris (2, 3-dihydroxybenzoyl) aminomethylbenzene (MECAM), and the natural siderophore enterobactin (ent) have been determined at 25 C. One of these compounds, 3, 4-LICAMS, was examined in detail, and the mechanism of its removal of iron from transferrin elucidated. The 3, 4-LICAMS ligand is observed to form a complex with transferrin prior to iron removal. The stability constant of this
ACS Publications