Pharmacokinetics of intravenous glycyrrhizin after single and multiple doses in patients with chronic hepatitis C infection
TGJ van Rossum, AG Vulto, WCJ Hop, SW Schalm - Clinical therapeutics, 1999 - Elsevier
Intravenous glycyrrhizin has been used in Japan for the treatment of chronic hepatitis for> 20
years, although only a few reports of its pharmacokinetic profile after multiple intravenous
doses in small numbers of Japanese patients have been published. The present study
compared these Japanese data against the pharmacokinetic characteristics of glycyrrhizin
after single and multiple intravenous doses in 35 European patients with chronic hepatitis C
infection. We administered 80, 160, or 240 mg glycyrrhizin 3 times/wk or 200 mg glycyrrhizin …
years, although only a few reports of its pharmacokinetic profile after multiple intravenous
doses in small numbers of Japanese patients have been published. The present study
compared these Japanese data against the pharmacokinetic characteristics of glycyrrhizin
after single and multiple intravenous doses in 35 European patients with chronic hepatitis C
infection. We administered 80, 160, or 240 mg glycyrrhizin 3 times/wk or 200 mg glycyrrhizin …