[HTML][HTML] Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress

H Hirota, J Chen, UAK Betz, K Rajewsky, Y Gu, J Ross… - Cell, 1999 - cell.com
H Hirota, J Chen, UAK Betz, K Rajewsky, Y Gu, J Ross, W Müller, KR Chien
Cell, 1999cell.com
Biomechanical stress is a major stimulus for cardiac hypertrophy and the transition to heart
failure. By generating mice that harbor a ventricular restricted knockout of the gp130
cytokine receptor via Cre-loxP-mediated recombination, we demonstrate a critical role for a
gp130-dependent myocyte survival pathway in the transition to heart failure. Such
conditional mutant mice have normal cardiac structure and function, but during aortic
pressure overload, these mice display rapid onset of dilated cardiomyopathy and massive …
Abstract
Biomechanical stress is a major stimulus for cardiac hypertrophy and the transition to heart failure. By generating mice that harbor a ventricular restricted knockout of the gp130 cytokine receptor via Cre-loxP-mediated recombination, we demonstrate a critical role for a gp130-dependent myocyte survival pathway in the transition to heart failure. Such conditional mutant mice have normal cardiac structure and function, but during aortic pressure overload, these mice display rapid onset of dilated cardiomyopathy and massive induction of myocyte apoptosis versus the control mice that exhibit compensatory hypertrophy. Thus, cardiac myocyte apoptosis is a critical point in the transition between compensatory cardiac hypertrophy and heart failure. gp130-dependent cytokines may represent a novel therapeutic strategy for preventing in vivo heart failure.
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