Gq signaling in cardiac adaptation and maladaptation

GW Dorn II, JH Brown - Trends in cardiovascular medicine, 1999 - Elsevier
Accumulating evidence suggests that cardiac responses to a number of circulating or locally
released humoral factors contribute to adaptive re-sponses after hemodynamic stress or
myocardial injury. In particular, hormones such as angiotensin II, endothelin 1,
norepinephrine and prostaglandin F2α which bind to and activate cardiomyocyte membrane
receptors coupled to the Gq class of GTP binding proteins have been implicated in the
development and ultimate decompensation of cardiac hypertrophy. Herein we summarize …