[HTML][HTML] Apoptosis repressor with caspase recruitment domain protects against cell death by interfering with Bax activation

AB Gustafsson, JG Tsai, SE Logue, MT Crow… - Journal of Biological …, 2004 - ASBMB
Myocardial ischemia/reperfusion (I/R) is associated with an extensive loss of myocardial
cells. The apoptosis repressor with caspase recruitment domain (ARC) is a protein that is
highly expressed in heart and skeletal muscle and has been demonstrated to protect the
heart against I/R injury (Gustafsson, AB, Sayen, MR, Williams, SD, Crow, MT, and Gottlieb,
RA (2002) Circulation 106, 735-739). In this study, we have shown that transduction of TAT-
ARCL31F, a mutant of ARC in the caspase recruitment domain, did not reduce creatine …