The mitochondrial death pathway and cardiac myocyte apoptosis
MT Crow, K Mani, YJ Nam, RN Kitsis - Circulation research, 2004 - Am Heart Assoc
MT Crow, K Mani, YJ Nam, RN Kitsis
Circulation research, 2004•Am Heart AssocApoptosis has been causally linked to the pathogenesis of myocardial infarction and heart
failure in rodent models. This death process is mediated by two central pathways, an
extrinsic pathway involving cell surface receptors and an intrinsic pathway using
mitochondria and the endoplasmic reticulum. Each of these pathways has been implicated
in myocardial pathology. In this review, we summarize recent advances in the understanding
of the intrinsic pathway and how it relates to cardiac myocyte death and heart disease.
failure in rodent models. This death process is mediated by two central pathways, an
extrinsic pathway involving cell surface receptors and an intrinsic pathway using
mitochondria and the endoplasmic reticulum. Each of these pathways has been implicated
in myocardial pathology. In this review, we summarize recent advances in the understanding
of the intrinsic pathway and how it relates to cardiac myocyte death and heart disease.
Apoptosis has been causally linked to the pathogenesis of myocardial infarction and heart failure in rodent models. This death process is mediated by two central pathways, an extrinsic pathway involving cell surface receptors and an intrinsic pathway using mitochondria and the endoplasmic reticulum. Each of these pathways has been implicated in myocardial pathology. In this review, we summarize recent advances in the understanding of the intrinsic pathway and how it relates to cardiac myocyte death and heart disease.
Am Heart Assoc