[HTML][HTML] Characterization of recombinant skeletal muscle (Ser-2843) and cardiac muscle (Ser-2809) ryanodine receptor phosphorylation mutants

M Stange, L Xu, D Balshaw, N Yamaguchi… - Journal of Biological …, 2003 - ASBMB
Phosphorylation of the skeletal muscle (RyR1) and cardiac muscle (RyR2) ryanodine
receptors has been reported to modulate channel activity. Abnormally high phosphorylation
levels (hyperphosphorylation) at Ser-2843 in RyR1 and Ser-2809 in RyR2 and dissociation
of FK506-binding proteins from the receptors have been implicated as one of the causes of
altered calcium homeostasis observed during human heart failure. Using site-directed
mutagenesis, we prepared recombinant RyR1 and RyR2 mutant receptors mimicking …