[HTML][HTML] The tumor suppressor gene PTEN can regulate cardiac hypertrophy and survival
G Schwartzbauer, J Robbins - Journal of Biological Chemistry, 2001 - ASBMB
Cardiac hypertrophy is a complex process involving the coordinated actions of many genes.
In a high throughput screen designed to identify transcripts that are actively translated during
cardiac hypertrophy, we identified a number of genes with established links to hypertrophy,
including those coding for Sp3, c-Jun, annexin II, cathepsin B, and HB-EGF, thus showing
the general utility of the screen. Focusing on a candidate transcript that has not been
previously linked to hypertrophy, we found that protein levels of the tumor suppressor PTEN …
In a high throughput screen designed to identify transcripts that are actively translated during
cardiac hypertrophy, we identified a number of genes with established links to hypertrophy,
including those coding for Sp3, c-Jun, annexin II, cathepsin B, and HB-EGF, thus showing
the general utility of the screen. Focusing on a candidate transcript that has not been
previously linked to hypertrophy, we found that protein levels of the tumor suppressor PTEN …