Transmembrane receptor tyrosine kinases have been shown to play an important role in the
modulation of growth factor signaling and regulation of key cellular processes. The erbB
receptor family is part of the receptor tyrosine kinase superfamily and consists of four
members, erbB-1, erbB-2, erbB-3, and erbB-4. A majority of solid tumors express one or
more members of this receptor family, and coexpression of multiple erbB receptors leads to
an enhanced transforming potential and worsened prognosis. The erbB receptor family has …