[HTML][HTML] Up-regulation of nuclear and mitochondrial genes in the skeletal muscle of mice lacking the heart/muscle isoform of the adenine nucleotide translocator

DG Murdock, BE Boone, LA Esposito… - Journal of Biological …, 1999 - ASBMB
Mice deficient in the heart/muscle specific isoform of the adenine nucleotide translocator
(ANT1) exhibit many of the hallmarks of human oxidative phosphorylation (OXPHOS)
disease, including a dramatic proliferation of skeletal muscle mitochondria. Because many
of the genes necessary for mitochondrial biosynthesis, OXPHOS function, and response to
OXPHOS disease might be expected to be up-regulated in theAnt1−/− mouse, we used
differential display reverse transcription-polymerase chain reaction techniques in an effort to …