The unfolded protein response pathway in Saccharomyces cerevisiae: oligomerization and trans-phosphorylation of Ire1p (Ern1p) are required for kinase activation
AA Welihinda, RJ Kaufman - Journal of Biological Chemistry, 1996 - jbc.org
In eukaryotic cells, accumulation of unfolded proteins in the endoplasmic reticulum (ER)
results in a transcriptional induction of a number of ER chaperone proteins. In
Saccharomyces cerevisiae, the putative transmembrane receptor kinase, Ire1p (Ern1p), has
been implicated as the sensor of unfolded proteins in the ER that initiates transmittance of
the unfolded protein signal from the ER to the nucleus. We have shown that the cytoplasmic
domain of Ire1p receptor indeed has intrinsic Ser/Thr kinase activity and contains Ser/Thr …
results in a transcriptional induction of a number of ER chaperone proteins. In
Saccharomyces cerevisiae, the putative transmembrane receptor kinase, Ire1p (Ern1p), has
been implicated as the sensor of unfolded proteins in the ER that initiates transmittance of
the unfolded protein signal from the ER to the nucleus. We have shown that the cytoplasmic
domain of Ire1p receptor indeed has intrinsic Ser/Thr kinase activity and contains Ser/Thr …