Transcriptional and translational control in the mammalian unfolded protein response
HP Harding, M Calfon, F Urano… - Annual review of cell …, 2002 - annualreviews.org
▪ Abstract Cells monitor the physiological load placed on their endoplasmic reticulum (ER)
and respond to perturbations in ER function by a process known as the unfolded protein
response (UPR). In metazoans the UPR has a transcriptional component that up-regulates
expression of genes that enhance the capacity of the organelle to deal with the load of client
proteins and a translational component that insures tight coupling between protein
biosynthesis on the cytoplasmic side and folding in the ER lumen. Together, these two …
and respond to perturbations in ER function by a process known as the unfolded protein
response (UPR). In metazoans the UPR has a transcriptional component that up-regulates
expression of genes that enhance the capacity of the organelle to deal with the load of client
proteins and a translational component that insures tight coupling between protein
biosynthesis on the cytoplasmic side and folding in the ER lumen. Together, these two …