[HTML][HTML] A role for kinesin in insulin-stimulated GLUT4 glucose transporter translocation in 3T3-L1 adipocytes
M Emoto, SE Langille, MP Czech - Journal of Biological Chemistry, 2001 - ASBMB
Insulin regulates glucose uptake in adipocytes and muscle by stimulating the movement of
sequestered glucose transporter 4 (GLUT4) proteins from intracellular membranes to the cell
surface. Here we report that optimal insulin-mediated GLUT4 translocation is dependent
upon both microtubule and actin-based cytoskeletal structures in cultured adipocytes.
Depolymerization of microtubules and F-actin in 3T3-L1 adipocytes causes the dispersion of
perinuclear GLUT4-containing membranes and abolishes insulin action on GLUT4 …
sequestered glucose transporter 4 (GLUT4) proteins from intracellular membranes to the cell
surface. Here we report that optimal insulin-mediated GLUT4 translocation is dependent
upon both microtubule and actin-based cytoskeletal structures in cultured adipocytes.
Depolymerization of microtubules and F-actin in 3T3-L1 adipocytes causes the dispersion of
perinuclear GLUT4-containing membranes and abolishes insulin action on GLUT4 …