Anti-fibrogenic effects of captopril and candesartan cilexetil on the hepatic fibrosis development in rat: the effect of AT1-R blocker on the hepatic fibrosis
Background/Aim: Angiotensin converting enzyme (ACE) and angiotensin II (AT-II) have been
suggested to play an important role in liver fibrogenesis. There is a significant relationship
between inheritance of hightened expression of transforming growth factor β1 (TGF-β1) and
AT-II and the development of progressive hepatic fibrosis. The purpose of this study was to
investigate the effects of captopril, an ACE inhibitor and candesartan cilexetil, an AT-II type 1
receptor (AT1-R) blocker, on liver fibrosis induced in rats by carbon tetrachloride (CCl4) …
suggested to play an important role in liver fibrogenesis. There is a significant relationship
between inheritance of hightened expression of transforming growth factor β1 (TGF-β1) and
AT-II and the development of progressive hepatic fibrosis. The purpose of this study was to
investigate the effects of captopril, an ACE inhibitor and candesartan cilexetil, an AT-II type 1
receptor (AT1-R) blocker, on liver fibrosis induced in rats by carbon tetrachloride (CCl4) …