Host genetic factors influence disease progression in chronic hepatitis C
EE Powell, CJ Edwards-Smith, JL Hay, AD Clouston… - Hepatology, 2000 - journals.lww.com
Progressive hepatic fibrosis and cirrhosis develops in 20% to 30% of patients with chronic
hepatitis C virus (HCV). We propose that host genetic factors influencing fibrogenesis may
account for some of the variability in progression of this disease. In progressive fibrosis of
other organs, particularly heart and kidney, production of the profibrogenic cytokine,
transforming growth factor β1 (TGF-β1), may be enhanced by angiotensin II, the principal
effector molecule of the renin-angiotensin system. The inheritance of polymorphisms in TGF …
hepatitis C virus (HCV). We propose that host genetic factors influencing fibrogenesis may
account for some of the variability in progression of this disease. In progressive fibrosis of
other organs, particularly heart and kidney, production of the profibrogenic cytokine,
transforming growth factor β1 (TGF-β1), may be enhanced by angiotensin II, the principal
effector molecule of the renin-angiotensin system. The inheritance of polymorphisms in TGF …