Apolipoprotein E polymorphism, a marker of disease severity in primary biliary cirrhosis?
C Corpechot, P Benlian, V Barbu, O Chazouillères… - Journal of …, 2001 - Elsevier
Background/Aims: To determine whether the apolipoprotein E (apo-E) polymorphism is
associated with the risk of primary biliary cirrhosis (PBC), the severity of the disease and its
response to ursodeoxycholic acid (UDCA) therapy. Methods: The apo-E genotype was
determined in 72 PBC patients. Genotype and allele distributions were compared with those
found in the French general population. Laboratory parameters obtained before and after 1-
and 4-year UDCA treatment were compared according to the apo-E allele carrier status …
associated with the risk of primary biliary cirrhosis (PBC), the severity of the disease and its
response to ursodeoxycholic acid (UDCA) therapy. Methods: The apo-E genotype was
determined in 72 PBC patients. Genotype and allele distributions were compared with those
found in the French general population. Laboratory parameters obtained before and after 1-
and 4-year UDCA treatment were compared according to the apo-E allele carrier status …