Genetic control of cell differentiation in the skeleton
P Ducy, G Karsenty - Current Opinion in Cell Biology, 1998 - Elsevier
P Ducy, G Karsenty
Current Opinion in Cell Biology, 1998•ElsevierThe mechanisms of cell differentiation in the skeleton are just beginning to be unraveled. In
the past year classical gene expression studies, genetic manipulation in mice and human
genetic approaches have led to the identification of Osf2/Cbfa1 as a major regulator of
osteoblast differentiation. Important progress was also made in the understanding of the
control of osteoclast differentiation through the identification of osteoprotegerin and its
ligand. These studies, as well as others of chondrocyte differentiation, provide a better …
the past year classical gene expression studies, genetic manipulation in mice and human
genetic approaches have led to the identification of Osf2/Cbfa1 as a major regulator of
osteoblast differentiation. Important progress was also made in the understanding of the
control of osteoclast differentiation through the identification of osteoprotegerin and its
ligand. These studies, as well as others of chondrocyte differentiation, provide a better …
The mechanisms of cell differentiation in the skeleton are just beginning to be unraveled. In the past year classical gene expression studies, genetic manipulation in mice and human genetic approaches have led to the identification of Osf2/Cbfa1 as a major regulator of osteoblast differentiation. Important progress was also made in the understanding of the control of osteoclast differentiation through the identification of osteoprotegerin and its ligand. These studies, as well as others of chondrocyte differentiation, provide a better understanding of skeletogenesis.
Elsevier