A-kinase anchoring proteins: protein kinase A and beyond
AS Edwards, JD Scott - Current opinion in cell biology, 2000 - Elsevier
AS Edwards, JD Scott
Current opinion in cell biology, 2000•ElsevierCompartmentalization of kinases and phosphatases is a key determinant in the specificity of
second messenger mediated signaling events. Localization of the cAMP-dependent protein
kinase (PKA) and other signaling enzymes is mediated by interaction with A-kinase
anchoring proteins (AKAPs). In the past year there have been many advances in our
understanding of AKAPs, particularly in the field of the functional consequences of PKA
anchoring.
second messenger mediated signaling events. Localization of the cAMP-dependent protein
kinase (PKA) and other signaling enzymes is mediated by interaction with A-kinase
anchoring proteins (AKAPs). In the past year there have been many advances in our
understanding of AKAPs, particularly in the field of the functional consequences of PKA
anchoring.
Compartmentalization of kinases and phosphatases is a key determinant in the specificity of second messenger mediated signaling events. Localization of the cAMP-dependent protein kinase (PKA) and other signaling enzymes is mediated by interaction with A-kinase anchoring proteins (AKAPs). In the past year there have been many advances in our understanding of AKAPs, particularly in the field of the functional consequences of PKA anchoring.
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