A tail of transdifferentiation

DL Stocum - Science, 2002 - science.org
DL Stocum
Science, 2002science.org
Cells switch allegiance. Developmental fate of NSCs in the regenerating axolotl tail. Most of
the NSCs in the growing ependymal tube differentiate into ectodermal derivatives: neurons,
glia, pigment cells, and fin mesenchyme. However, some ectodermal NSCs
transdifferentiate into mesodermal lineages, becoming muscle cells or chondrocytes that
form cartilage.
Cells switch allegiance. Developmental fate of NSCs in the regenerating axolotl tail. Most of the NSCs in the growing ependymal tube differentiate into ectodermal derivatives: neurons, glia, pigment cells, and fin mesenchyme. However, some ectodermal NSCs transdifferentiate into mesodermal lineages, becoming muscle cells or chondrocytes that form cartilage.
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