[HTML][HTML] Protein kinase C-ζ regulates transcription of the matrix metalloproteinase-9 gene induced by IL-1 and TNF-α in glioma cells via NF-κB
PO Estève, E Chicoine, O Robledo, F Aoudjit… - Journal of Biological …, 2002 - ASBMB
The regulation of matrix metalloproteinase-9 (MMP-9) expression in glioma cells is one of
the key processes in tumor invasion through the brain extracellular matrix. Although some
studies have demonstrated the implication of classic protein kinase C (PKC) isoforms in the
regulation of MMP-9 production by phorbol esters or lipopolysaccharide, the involvement of
specific PKC isoforms in the signaling pathways leading to MMP-9 expression by
inflammatory cytokines remains unclear. Here we report that the atypical PKC-ζ isoform …
the key processes in tumor invasion through the brain extracellular matrix. Although some
studies have demonstrated the implication of classic protein kinase C (PKC) isoforms in the
regulation of MMP-9 production by phorbol esters or lipopolysaccharide, the involvement of
specific PKC isoforms in the signaling pathways leading to MMP-9 expression by
inflammatory cytokines remains unclear. Here we report that the atypical PKC-ζ isoform …
