Platelet-derived growth factor receptor-beta is induced during tumor development and upregulated during tumor progression in endothelial cells in human gliomas.
Laboratory investigation; a journal of technical methods and pathology, 1992•europepmc.org
Background Endothelial cells proliferate during brain development, are quiescent in normal
adult brain but proliferate again under pathologic conditions such as glioma growth. The
vascular phenotype of low grade glioma is comparable to normal brain, however high grade
gliomas are focally highly vascularized and there is associated prominent endothelial cell
proliferation. The mechanisms of this change in vascular phenotype are unknown but there
is evidence that growth factors play an important role in this process as well as in normal …
adult brain but proliferate again under pathologic conditions such as glioma growth. The
vascular phenotype of low grade glioma is comparable to normal brain, however high grade
gliomas are focally highly vascularized and there is associated prominent endothelial cell
proliferation. The mechanisms of this change in vascular phenotype are unknown but there
is evidence that growth factors play an important role in this process as well as in normal …
Background
Endothelial cells proliferate during brain development, are quiescent in normal adult brain but proliferate again under pathologic conditions such as glioma growth. The vascular phenotype of low grade glioma is comparable to normal brain, however high grade gliomas are focally highly vascularized and there is associated prominent endothelial cell proliferation. The mechanisms of this change in vascular phenotype are unknown but there is evidence that growth factors play an important role in this process as well as in normal angiogenesis and vascular differentiation.
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