[HTML][HTML] Adaptor proteins Grb2 and Crk couple Pyk2 with activation of specific mitogen-activated protein kinase cascades
A Blaukat, I Ivankovic-Dikic, E Grönroos, F Dolfi… - Journal of Biological …, 1999 - ASBMB
The protein tyrosine kinase Pyk2 acts as an upstream regulator of mitogen-activated protein
(MAP) kinase cascades in response to numerous extracellular signals. The precise
molecular mechanisms by which Pyk2 activates distinct MAP kinase pathways are not yet
fully understood. In this report, we provide evidence that the protein tyrosine kinase Src and
adaptor proteins Grb2, Crk, and p130Cas act as downstream mediators of Pyk2 leading to
the activation of extracellular signal-regulated kinase (ERK) and c-Jun amino-terminal …
(MAP) kinase cascades in response to numerous extracellular signals. The precise
molecular mechanisms by which Pyk2 activates distinct MAP kinase pathways are not yet
fully understood. In this report, we provide evidence that the protein tyrosine kinase Src and
adaptor proteins Grb2, Crk, and p130Cas act as downstream mediators of Pyk2 leading to
the activation of extracellular signal-regulated kinase (ERK) and c-Jun amino-terminal …