MyD88-Deficient Mice Display a Profound Loss in Resistance to Mycobacterium tuberculosis Associated with Partially Impaired Th1 Cytokine and Nitric Oxide …

CA Scanga, A Bafica, CG Feng, AW Cheever… - Infection and …, 2004 - Am Soc Microbiol
CA Scanga, A Bafica, CG Feng, AW Cheever, S Hieny, A Sher
Infection and immunity, 2004Am Soc Microbiol
Mycobacterium tuberculosis possesses agonists for several Toll-like receptors (TLRs), yet
mice with single TLR deletions are resistant to acute tuberculosis. MyD88−/− mice were
used to examine whether TLRs play any role in protection against aerogenic M. tuberculosis
H37Rv infection. MyD88−/− mice failed to control mycobacterial replication and rapidly
succumbed. Moreover, expressions of interleukin 12, tumor necrosis factor alpha, gamma
interferon, and nitric oxide synthase 2 were markedly decreased in the knockout animals …
Abstract
Mycobacterium tuberculosis possesses agonists for several Toll-like receptors (TLRs), yet mice with single TLR deletions are resistant to acute tuberculosis. MyD88−/− mice were used to examine whether TLRs play any role in protection against aerogenic M. tuberculosis H37Rv infection. MyD88−/− mice failed to control mycobacterial replication and rapidly succumbed. Moreover, expressions of interleukin 12, tumor necrosis factor alpha, gamma interferon, and nitric oxide synthase 2 were markedly decreased in the knockout animals. These results argue that resistance to M. tuberculosis must depend on MyD88-dependent signals mediated by an as-yet-undetermined TLR or a combination of TLRs.
American Society for Microbiology