Chemotaxis Inhibitory Protein of Staphylococcus aureus, a Bacterial Antiinflammatory Agent

CJC de Haas, KE Veldkamp, A Peschel… - The Journal of …, 2004 - rupress.org
CJC de Haas, KE Veldkamp, A Peschel, F Weerkamp, WJB Van Wamel, ECJM Heezius…
The Journal of experimental medicine, 2004rupress.org
Leukocyte migration is a key event both in host defense against invading pathogens as well
as in inflammation. Bacteria generate chemoattractants primarily by excretion (formylated
peptides), complement activation (C5a), and subsequently through activation of leukocytes
(eg, leukotriene B4, platelet-activating factor, and interleukin 8). Here we describe a new
protein secreted by Staphylococcus aureus that specifically impairs the response of
neutrophils and monocytes to formylated peptides and C5a. This chemotaxis inhibitory …
Leukocyte migration is a key event both in host defense against invading pathogens as well as in inflammation. Bacteria generate chemoattractants primarily by excretion (formylated peptides), complement activation (C5a), and subsequently through activation of leukocytes (e.g., leukotriene B4, platelet-activating factor, and interleukin 8). Here we describe a new protein secreted by Staphylococcus aureus that specifically impairs the response of neutrophils and monocytes to formylated peptides and C5a. This chemotaxis inhibitory protein of S. aureus (CHIPS) is a 14.1-kD protein encoded on a bacteriophage and is found in >60% of clinical isolates. CHIPS reduces the neutrophil recruitment toward C5a in a mouse peritonitis model, even though its activity is much more potent on human than on mouse cells. These findings suggest a new immune escape mechanism of S. aureus and put forward CHIPS as a potential new antiinflammatory therapeutic compound.
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