[HTML][HTML] Protein Kinase C ϵ Dependence of the Recovery from Down-regulation of S1P1 G Protein-coupled Receptors of T Lymphocytes
MH Graeler, Y Kong, JS Karliner, EJ Goetzl - Journal of Biological …, 2003 - ASBMB
Sphingosine 1-phosphate (S1P) from mononuclear phagocytes and platelets signals T cells
predominantly through S1P 1 G protein-coupled receptors (Rs) to enhance survival,
stimulate and suppress migration, and inhibit other immunologically relevant responses.
Cellular S1P 1 Rs and their signaling functions are rapidly down-regulated by S1P, through
a protein kinase C (PKC)-independent mechanism, but characteristics of cell-surface re-
expression of down-regulated S1P 1 Rs have not been elucidated. T cell chemotactic …
predominantly through S1P 1 G protein-coupled receptors (Rs) to enhance survival,
stimulate and suppress migration, and inhibit other immunologically relevant responses.
Cellular S1P 1 Rs and their signaling functions are rapidly down-regulated by S1P, through
a protein kinase C (PKC)-independent mechanism, but characteristics of cell-surface re-
expression of down-regulated S1P 1 Rs have not been elucidated. T cell chemotactic …