Update in podocyte biology

K Endlich, W Kriz, R Witzgall - Current Opinion in Nephrology and …, 2001 - journals.lww.com
K Endlich, W Kriz, R Witzgall
Current Opinion in Nephrology and Hypertension, 2001journals.lww.com
Abstract Knowledge of podocyte biology is growing rapidly. Podocytes are crucially involved
in most hereditary diseases affecting the glomerulus, which all exhibit podocyte-specific
defects, that is, foot process effacement and protein leakage. Efforts to understand molecular
mechanisms causing these derangements are increasingly successful and will allow a
better targeting of interventions to halt the progression of chronic renal disease.
Abstract
Knowledge of podocyte biology is growing rapidly. Podocytes are crucially involved in most hereditary diseases affecting the glomerulus, which all exhibit podocyte-specific defects, that is, foot process effacement and protein leakage. Efforts to understand molecular mechanisms causing these derangements are increasingly successful and will allow a better targeting of interventions to halt the progression of chronic renal disease.
Lippincott Williams & Wilkins