The glomerular slit diaphragm is a modified adherens junction
J Reiser, W Kriz, M Kretzler… - Journal of the American …, 2000 - journals.lww.com
The glomerular slit diaphragm between podocyte foot processes shares typical morphologic
features with an adherens junction. Differentiated cultured podocytes form cellular structures
comparable to filtration slits in vivo. At those sites, zonula occludens-1 (ZO-1) was
coexpressed with P-cadherin as well as with α-, β-, and γ-catenin. In situ, P-cadherin was
detected at the slit diaphragm in association with ZO-1 as shown by confocal microscopy
and immunogold double labeling electron microscopy. P-cadherin expression in vivo and in …
features with an adherens junction. Differentiated cultured podocytes form cellular structures
comparable to filtration slits in vivo. At those sites, zonula occludens-1 (ZO-1) was
coexpressed with P-cadherin as well as with α-, β-, and γ-catenin. In situ, P-cadherin was
detected at the slit diaphragm in association with ZO-1 as shown by confocal microscopy
and immunogold double labeling electron microscopy. P-cadherin expression in vivo and in …