[HTML][HTML] Polycystin-1 activation of c-Jun N-terminal kinase and AP-1 is mediated by heterotrimeric G proteins
SC Parnell, BS Magenheimer, RL Maser… - Journal of Biological …, 2002 - ASBMB
Functional analysis of polycystin-1, the product of the gene most frequently mutated in
autosomal dominant polycystic kidney disease, has revealed that this protein is involved in
the regulation of diverse signaling pathways such as the activation of the transcription factor
AP-1 and modulation of Wnt signaling. However, the initial steps involved in the activation of
such cascades have remained unclear. We demonstrated previously that the C-terminal
cytosolic tail of polycystin-1 binds and activates heterotrimeric G proteins in vitro. To test if …
autosomal dominant polycystic kidney disease, has revealed that this protein is involved in
the regulation of diverse signaling pathways such as the activation of the transcription factor
AP-1 and modulation of Wnt signaling. However, the initial steps involved in the activation of
such cascades have remained unclear. We demonstrated previously that the C-terminal
cytosolic tail of polycystin-1 binds and activates heterotrimeric G proteins in vitro. To test if …