[HTML][HTML] Polycystin-1 distribution is modulated by polycystin-2 expression in mammalian cells

DH Grimm, Y Cai, V Chauvet, V Rajendran… - Journal of Biological …, 2003 - ASBMB
Mutations in PKD1 and PKD2, the genes that encode polycystin-1 and polycystin-2
respectively, account for almost all cases of autosomal dominant polycystic kidney disease.
Although the polycystins are believed to interact in vivo, the two proteins often display
dissimilar patterns and gradients of expression during development. In an effort to
understand this apparent discrepancy, we investigated how changes in polycystin-2
expression can affect the subcellular localization of polycystin-1. We show that, when …