CD1-specific T cells in microbial immunity
JE Gumperz, MB Brenner - Current opinion in immunology, 2001 - Elsevier
JE Gumperz, MB Brenner
Current opinion in immunology, 2001•ElsevierRecent results strengthen evidence that CD1-restricted T cells play important roles in host
defense against microbial infections. Human subjects recently infected with Mycobacterium
tuberculosis showed elevated responses to CD1c-mediated presentation of a microbial lipid
antigen, compared with control donors. Activation of CD1d-restricted NKT cells with a
synthetic glycolipid antigen results in improved immune responses to several infectious
pathogens.
defense against microbial infections. Human subjects recently infected with Mycobacterium
tuberculosis showed elevated responses to CD1c-mediated presentation of a microbial lipid
antigen, compared with control donors. Activation of CD1d-restricted NKT cells with a
synthetic glycolipid antigen results in improved immune responses to several infectious
pathogens.
Recent results strengthen evidence that CD1-restricted T cells play important roles in host defense against microbial infections. Human subjects recently infected with Mycobacterium tuberculosis showed elevated responses to CD1c-mediated presentation of a microbial lipid antigen, compared with control donors. Activation of CD1d-restricted NKT cells with a synthetic glycolipid antigen results in improved immune responses to several infectious pathogens.
Elsevier