Murine natural killer cells contribute to the granulomatous reaction caused by mycobacterial cell walls

I Apostolou, Y Takahama, C Belmant… - Proceedings of the …, 1999 - National Acad Sciences
I Apostolou, Y Takahama, C Belmant, T Kawano, M Huerre, G Marchal, J Cui, M Taniguchi…
Proceedings of the National Academy of Sciences, 1999National Acad Sciences
Mice injected with deproteinized cell walls prepared from the strain H37rv of Mycobacterium
tuberculosis develop a granuloma-like lesion in which NKT cells are predominant. NKT cells
play a primary role in the granulomatous response, because the latter does not occur in
Jα281−/− mice, which miss NKT cells. The glycolipidic fraction of the cell walls is responsible
for the recruitment of NKT cells; the recruiting activity is associated with fractions containing
phosphatidylinositolmannosides. These results define a powerful experimental set up for …
Mice injected with deproteinized cell walls prepared from the strain H37rv of Mycobacterium tuberculosis develop a granuloma-like lesion in which NKT cells are predominant. NKT cells play a primary role in the granulomatous response, because the latter does not occur in Jα281−/− mice, which miss NKT cells. The glycolipidic fraction of the cell walls is responsible for the recruitment of NKT cells; the recruiting activity is associated with fractions containing phosphatidylinositolmannosides. These results define a powerful experimental set up for studying the in vivo induction of NKT cell responses to microbial components.
National Acad Sciences