[HTML][HTML] Phosphorylation of c-Crk II on the negative regulatory Tyr222 mediates nerve growth factor-induced cell spreading and morphogenesis
M Escalante, J Courtney, WG Chin, KK Teng… - Journal of Biological …, 2000 - ASBMB
The Crk family of adaptor proteins participate in diverse signaling pathways that regulate
growth factor-induced proliferation, anchorage-dependent DNA synthesis, and cytoskeletal
reorganization, important for cell adhesion and motility. Using kidney epithelial 293T cells for
transient co-transfection studies and the nerve growth factor (NGF)-responsive PC12 cell
line as a model system for neuronal morphogenesis, we demonstrate that the non-receptor
tyrosine kinase c-Abl is an intermediary for NGF-inducible c-Crk II phosphorylation on the …
growth factor-induced proliferation, anchorage-dependent DNA synthesis, and cytoskeletal
reorganization, important for cell adhesion and motility. Using kidney epithelial 293T cells for
transient co-transfection studies and the nerve growth factor (NGF)-responsive PC12 cell
line as a model system for neuronal morphogenesis, we demonstrate that the non-receptor
tyrosine kinase c-Abl is an intermediary for NGF-inducible c-Crk II phosphorylation on the …