The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans
K Kornfeld, DB Hom, HR Horvitz - Cell, 1995 - cell.com
K Kornfeld, DB Hom, HR Horvitz
Cell, 1995•cell.comBy screening for mutations that suppress the vulva1 defects caused by a constitutively active
let-60 ras gene, we identified six loss-of-function alleles of ksr-7, a novel C. elegans gene.
Our genetic analysis showed ksr-7 positively mediates Ras signaling and functions
downstream of or in parallel to let-60. In the absence of ksr-7 function, normal Ras signaling
is impaired only slightly, suggesting ksr-7 may act to modulate, or in a branch that diverges
from, the main signaling pathway. The predicted KSR-1 protein has a protein kinase domain …
let-60 ras gene, we identified six loss-of-function alleles of ksr-7, a novel C. elegans gene.
Our genetic analysis showed ksr-7 positively mediates Ras signaling and functions
downstream of or in parallel to let-60. In the absence of ksr-7 function, normal Ras signaling
is impaired only slightly, suggesting ksr-7 may act to modulate, or in a branch that diverges
from, the main signaling pathway. The predicted KSR-1 protein has a protein kinase domain …
Summary
By screening for mutations that suppress the vulva1 defects caused by a constitutively active let-60 ras gene, we identified six loss-of-function alleles of ksr-7, a novel C. elegans gene. Our genetic analysis showed ksr-7 positively mediates Ras signaling and functions downstream of or in parallel to let-60. In the absence of ksr-7 function, normal Ras signaling is impaired only slightly, suggesting ksr-7 may act to modulate, or in a branch that diverges from, the main signaling pathway. The predicted KSR-1 protein has a protein kinase domain and is most similar to a recently identified Drosophila protein involved in Ras signaling. We propose that the function of ksr-7 is evolutionarily conserved.
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