Characterization of dermatitis arising spontaneously in DS-Nh mice maintained under conventional conditions: another possible model for atopic dermatitis
I Hikita, T Yoshioka, T Mizoguchi, K Tsukahara… - Journal of …, 2002 - Elsevier
DS-Nh (DS Nh/+) mice spontaneously develop dermatitis when they are housed in a
conventional environment. In this study, we analyzed the clinical and histopathological
features of dermatitis in DS-Nh mice, which is characterized by erythema, edema, and
erosion on the face, neck, chest and flexor surfaces of their forelegs with marked scratching
behavior. Histopathological examination, including immunohistochemistry, revealed that
inflammatory cells consisting of mast cells, eosinophils, CD4-positive T cell-dominant …
conventional environment. In this study, we analyzed the clinical and histopathological
features of dermatitis in DS-Nh mice, which is characterized by erythema, edema, and
erosion on the face, neck, chest and flexor surfaces of their forelegs with marked scratching
behavior. Histopathological examination, including immunohistochemistry, revealed that
inflammatory cells consisting of mast cells, eosinophils, CD4-positive T cell-dominant …
