Neutrophils play major roles in inducing cutane-ous tissue injury observed in neutrophilic
dermatoses by secreting a variety of inflammatory products. Among them, reactive oxygen
species (ROS) are of great importance. 1, 2 Neutrophils are known to transform molecular
oxygen to superoxide anion via a membrane enzyme system and coupled oxidation. A
further respiratory burst results in the highly reactive oxidants, which are produced primarily
to aid in the killing of invaded microorganisms as one of the selfdefense mechanisms …